The ex-Apprentice star said the country's schools and hospitals are "full" and that the UK should only let in "tier one" individuals who are skilled.
Talking about the issue on the Channel 5 programme, Mrs Hopkins said: "Nobody is standing up for the people at home who have had enough of immigration.
"Of queuing for school places, at doctors. Frankly, if you need an interpreter to get a doctor's appointment you shouldn't be using our NHS.
"If you need an interpreter then you need a travel agent and should get packing.
"Hard working people in this country have had enough."Mrs Hopkins also came to blows with fellow former Apprentice star Luisa Zissman who is in favour of immigration.
Miss Zissman was giving her reasons for why she was in favour of immigration when Mrs Hopkins abruptly interrupted her to say she disagreed.
Miss Zissman said: "I think British people don't work hard enough. British people always say immigrants are coming in and taking our jobs - they're not. Some of the jobs immigrants are doing are the ones British people won't do.
"Every economy needs jobs that are low wage."
Then Mrs Hopkins cut in: "Wiffle piffle. There are plenty of people who aren't getting off their a**** and doing work.
"We need to get lazy British people out to work."
And she caused anger among the audience when she was asked whether she would let her children play with a youngster called Muhammad.
Mrs Hopkins said: "If you go into a playground and shout Muhammad you would probably get 100 kids running towards you.
"Auntie won't have this debate because they're afraid of people calling us racist.
"I do not make stupid statements, I stand up for people who feel what I feel.
"I am not a racist because I believe there should be a universal treatment for everyone."
Elsewhere on the debate, an interview was broadcast of radical preacher Anjem Choudary with Nick Ferrari who was hosting the debate with Anne Diamond.
Choudary warned Britain that the death of Fusilier Lee Rigby may not be a one-off shock incident.
The extremist Muslim cleric said "there will be other Lee Rigbys" on UK shores.
Choudary said: "Afghanistan is not occupying Britain. Britain (sic) are going to Muslim countries and killing people.
"This will have repercussions in this country and unless we wake up to this fact, there will be other Lee Rigbys."
The father-of-one, 25, was murdered by Michael Adebowale, 22, and his accomplice Michael Adebolajo, 29 near Woolwich Barracks last May.
They were found guilty of murder last December and will be sentenced on February 20.
Choudary also said that immigrants hold a "fear factor" for people in the UK.
He was referring to results of a YouGov poll commissioned for The Big British Immigration Row: Live.
The exclusive research found out that 70 per cent of Britons want immigration to be reduced or stopped completely in the UK.
Choudary said: "There is a fear factor - that the foreigner is causing trouble for them".
He blamed the recession for this attitude and felt Britons thought that immigrants were putting a burden on the National Health Service.
